Anti-prion Butenolides and Diphenylpropanones from the Australian Ascidian Polycarpa procera.
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DOI: 10.1021/acs.jnatprod.9b00551
Abstract: A library of 500 Australian marine invertebrate extracts was screened for anti-prion activity using a yeast-based assay, and this resulted in an extract from the ascidian Polycarpa procera showing potent activity. Purification of this extract… read more here.
Keywords: prion; anti prion; ascidian polycarpa; polycarpa procera ... See more keywords
Synthesis and Biological Activity of Glycosyl Thiazolyl Disulfides Based on Thiacarpine, an Analogue of the Cytotoxic Alkaloid Polycarpine from the Ascidian Polycarpa aurata
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DOI: 10.3390/md23030117
Abstract: Polycarpine, a diimidazolyl disulfan alkaloid isolated from the ascidian Polycarpa aurata, showed high cytotoxic activity in vitro. However, in vivo experiments have shown that polycarpine has a high acute toxicity. At the same time, its… read more here.
Keywords: polycarpa aurata; ascidian polycarpa; polycarpine; cytotoxic ... See more keywords