Capturing tumour heterogeneity in pre- and post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing
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DOI: 10.1042/bsr20212093
Abstract: Abstract Malignant ascites is an abnormal accumulation of fluid within the peritoneal cavity, caused by metastasis of several types of cancers, including colorectal cancer (CRC). Cancer cells in ascites reflect poor prognosis and serve as… read more here.
Keywords: chemotherapy; derived cells; cancer; cell ... See more keywords
Characterization of ascites‐derived tumor cells from an endometrial cancer patient
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DOI: 10.1111/cas.13407
Abstract: Improved treatment outcomes for the endometrial cancer patient requires precision methods to investigate the biology of this disease and clinically relevant models to test treatment drugs. Hence, we applied a personalized platform to investigate whether… read more here.
Keywords: derived tumor; tumor cells; endometrial cancer; ascites derived ... See more keywords
Loss of Krüppel‐like factor 9 facilitates stemness in ovarian cancer ascites‐derived multicellular spheroids via Notch1/slug signaling
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DOI: 10.1111/cas.15100
Abstract: The ascites that develops in advanced OC, both at diagnosis and upon recurrence, is a rich source of multicellular spheroids/aggregates (MCSs/MCAs), which are the major seeds of tumor cell dissemination within the abdominal cavity. However,… read more here.
Keywords: like factor; ppel like; ascites derived; cancer ... See more keywords
Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells
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DOI: 10.18632/oncotarget.15040
Abstract: Malignant ascites-derived exosomes have been demonstrated to participate in tumor metastasis. In peritoneal metastasis, normal mesothelial cells (MCs) can be converted into carcinoma-associated fibroblasts (CAFs) by mesothelial-mesenchymal transition (MMT). Herein, we evaluated the effect of… read more here.
Keywords: malignant ascites; associated fibroblasts; carcinoma associated; mesothelial cells ... See more keywords
Accumulation and suppressive function of regulatory T cells in malignant ascites: Reducing their suppressive function using arsenic trioxide in vitro
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DOI: 10.3892/ol.2018.7974
Abstract: Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by… read more here.
Keywords: arsenic trioxide; malignant ascites; regulatory cells; ascites derived ... See more keywords