Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by downregulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway.
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DOI: 10.1042/cs20200452
Abstract: BACKGROUNDS/AIMS This study explores the potential of chronic treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks… read more here.
Keywords: txa2 pathway; iso; cox txa2; cirrhotic rats ... See more keywords