ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.06.002
Abstract: The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally… read more here.
Keywords: lung adenocarcinoma; ascl1; ascl1 positive; cell ... See more keywords
Miro, a mitochondrial outer membrane protein interacts with Alzheimer’s disease related genes in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.350
Abstract: During development, cortical interneurons generated from the ventral telencephalon migrate tangentially into the dorsal telencephalon. AlthoughAchaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in the developing telencephalon, whether Ascl1 regulates tangential migration remains… read more here.
Keywords: tangential migration; outer membrane; ascl1; dorsal telencephalon ... See more keywords
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0248-7
Abstract: Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the… read more here.
Keywords: gene ascl1; expression; ascl1; transcriptional subgroup ... See more keywords
Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1
Sign Up to like & getrecommendations! Published in 2025 at "Open Biology"
DOI: 10.1098/rsob.250018
Abstract: ASCL1 is a key member of the proneural basic helix-loop-helix (bHLH) transcription factor (TF) family and it plays diverse roles in nervous system development and maintenance. ASCL1 is also one of the most studied bHLH… read more here.
Keywords: cell; cell fate; transcription factor; ascl1 ... See more keywords
ASCL1 regulates super‐enhancer‐associated miRNAs to define molecular subtypes of small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15481
Abstract: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor with dismal prognosis. Recently, molecular subtypes of SCLC have been defined by the expression status of ASCL1, NEUROD1, YAP1, and POU2F3 transcription regulators. ASCL1… read more here.
Keywords: molecular subtypes; associated mirnas; small cell; ascl1 ... See more keywords
Abstract 4730: ASCL1 activates neuronal stem cell-like lineage programming through the remodeling of the chromatin landscape in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4730
Abstract: Introduction: Second-generation AR pathway inhibitors such as Enzalutamide (ENZ) are highly effective in treating castration-resistant prostate cancer (CRPC). However, they play an important role in the emergence of AR-independent phenotypes, including treatment-induced neuroendocrine prostate cancer… read more here.
Keywords: cell; prostate cancer; ascl1; chromatin ... See more keywords
Abstract PR004: Exploring the role of ASCL1 in neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-pr004
Abstract: Most patients with prostate adenocarcinoma (PAd), an androgen receptor (AR) driven cancer, develop resistance to therapies targeting AR. Consequently, a portion of these patients develop neuroendocrine prostate cancer (NEPC), a rapidly progressing cancer with limited… read more here.
Keywords: prostate cancer; small cell; ascl1; histology ... See more keywords
ASCL1 regulates and cooperates with FOXA2 to drive terminal neuroendocrine phenotype in prostate cancer
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.185952
Abstract: Lineage plasticity mediates resistance to androgen receptor pathway inhibitors (ARPIs) and progression from adenocarcinoma to neuroendocrine prostate cancer (NEPC), a highly aggressive and poorly understood subtype. Neuronal transcription factor ASCL1 has emerged as a central… read more here.
Keywords: ascl1; nepc; prostate cancer; lineage ... See more keywords
The N terminus of Ascl1 underlies differing proneural activity of mouse and Xenopus Ascl1 proteins
Sign Up to like & getrecommendations! Published in 2018 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.14842.1
Abstract: The proneural basic-helix-loop-helix (bHLH) transcription factor Ascl1 is a master regulator of neurogenesis in both central and peripheral nervous systems in vivo, and is a central driver of neuronal reprogramming in vitro. Over the last… read more here.
Keywords: xenopus; activity mouse; ascl1; protein ... See more keywords
ASCL1 promotes Scrt2 expression in the neural tube
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1324584
Abstract: ASCL1 is a transcription factor that directs neural progenitors towards lineage differentiation. Although many of the molecular mechanisms underlying its action have been described, several of its targets remain unidentified. We identified in the chick… read more here.
Keywords: scrt2 expression; expression neural; neural tube; ascl1 ... See more keywords
An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1546794
Abstract: Objective Our previous study found that Achaete-scute complex homolog 1 (ASCL1) is involved in classifying BC subtypes with different prognostic and pathological characteristics. However, the biological role of ASCL1 in BC still remains largely unexplored.… read more here.
Keywords: ascl1; inhibition ascl1; cell; sensitivity ... See more keywords