ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
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DOI: 10.1016/j.canlet.2020.06.002
Abstract: The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally… read more here.
Keywords: lung adenocarcinoma; ascl1; ascl1 positive; cell ... See more keywords
Abstract LB259: Distinct microRNA signature and suppression of ZFP36L1 define ASCL1-positive lung adenocarcinoma
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DOI: 10.1158/1538-7445.am2023-lb259
Abstract: Background: Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas and exerts tumor-promoting effects. However, microRNA (miRNA) profiles regulated… read more here.
Keywords: lung adenocarcinoma; ascl1 positive; positive lung; lung ... See more keywords