The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.022
Abstract: Aberrant Wnt/β-catenin signaling is a common event during human colorectal cancer (CRC) development. Previously, we characterized members of the L1 family of cell adhesion receptors as targets of β-catenin-LEF1/TCF transactivation that are expressed at the… read more here.
Keywords: ascl2; intestinal stem; stem cell; cancer ... See more keywords
TNFα-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "Aging and Disease"
DOI: 10.14336/ad.2018.1028
Abstract: The molecular mediators underlying the effects of inflammation on neural stem cells (NSCs) are not fully characterized. In this study, we identified Ascl2 as a downstream basic helix-loop-helix (bHLH) transcription factor in NSCs following exposure… read more here.
Keywords: ascl2; regulation; neural stem; regulation ascl2 ... See more keywords