Chloroplastic ascorbate peroxidases targeted to stroma or thylakoid membrane: The chicken or egg dilemma
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14438
Abstract: Ascorbate peroxidases (APXs) are heme peroxidases that remove hydrogen peroxide in different subcellular compartments with concomitant ascorbate cycling. Here, we analysed and discussed phylogenetic and molecular features of the APX family. Ancient APX originated as… read more here.
Keywords: ascorbate peroxidases; ascorbate; thylakoid membrane; peroxidases targeted ... See more keywords
A non‐precious metal ascorbate fuel cell
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Energy Research"
DOI: 10.1002/er.6565
Abstract: The requirement of expensive precious metal catalysts as electrode materials in fuel cells remains a major obstacle to commercialization. In this work, two ascorbate fuel cells are fabricated without precious metal catalysts and are operated… read more here.
Keywords: ascorbate; fuel cell; ascorbate fuel; precious metal ... See more keywords
Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen
Sign Up to like & getrecommendations! Published in 2021 at "Human Cell"
DOI: 10.1007/s13577-020-00462-3
Abstract: Carcinostatic effects of combined use of ascorbic acid (Asc), 2- O -phospho- or 6- O -palmitoyl ascorbate (Asc2Phos, Asc6Palm) or diverse alkanoyl Asc, and nano-sized platinum-poly( N -vinyl-pyrrolidone) colloid (PVP–Pt; 2-nm diameter) were examined on… read more here.
Keywords: ascorbate; hydrogen; water; asc ... See more keywords
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.058
Abstract: BACKGROUND Increased endothelial permeability is central to shock and organ dysfunction in sepsis but therapeutics targeted to known mediators of increased endothelial permeability have been unsuccessful in patient studies. We previously reported that cell-free hemoglobin… read more here.
Keywords: ascorbate; endothelial permeability; cell free; permeability ... See more keywords
Fabrication of ordered polydopamine-coated carbon nanotube arrays and their electrocatalytic activities towards synergistically enhanced oxidation of ascorbate-monosaccharides and reduction of oxygen
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.04.181
Abstract: Abstract An ordered array of single-walled carbon nanotubes coated with polydopamine (SWCNTs@PDA) is prepared using multiple voltammetry for the oxidation of ascorbate (AA)-monosaccharides, and the reduction of oxygen (O2) in enzyme-free fuel cells. The SWCNTs@PDA… read more here.
Keywords: ascorbate; oxidation ascorbate; swcnts pda; ascorbate monosaccharides ... See more keywords
Light regulation of vitamin C in tomato fruit is mediated through photosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2018.12.002
Abstract: Abstract Higher levels of irradiance result in higher accumulation of ascorbate in leaves and fruits. Photosynthesis and respiration are an integral part of the physiological mechanism of light regulation of ascorbate in leaves, but little… read more here.
Keywords: light; ascorbate; tomato fruit; fruit ... See more keywords
Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.09.008
Abstract: Abstract An ascorbate‐mediated production of oxidative stress has been shown to retard tumor growth. Subsequent glycolysis inhibition has been suggested. Here, we further define the mechanisms relevant to this observation. Ascorbate was cytotoxic to human… read more here.
Keywords: parp; ascorbate; dna damage; cell death ... See more keywords
Inhibition of Peroxide Removal Enhances Pharmacological Ascorbate and Ionizing Radiation-Induced Cytotoxicity of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.144
Abstract: Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer deaths with a poor 5 year survival rate of only 8.2%. PDA cells produce high levels of reactive oxygen species (ROS) compared to normal… read more here.
Keywords: ascorbate; peroxide removal; pda; pharmacological ascorbate ... See more keywords
Ascorbate and ferritin interactions: Consequences for iron release in vitro and in vivo and implications for inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.09.041
Abstract: ABSTRACT This review discusses the chemical mechanisms of ascorbate‐dependent reduction and solubilization of ferritin's ferric iron core and subsequent release of ferrous iron. The process is accelerated by low concentrations of Fe(II) that increase ferritin's… read more here.
Keywords: iron release; ascorbate; ferritin; ferritin iron ... See more keywords
Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.08.002
Abstract: Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by astrocytes during glutamate clearance and disruption of this exchange mechanism may… read more here.
Keywords: ascorbate; ascorbate deficient; mice; deficient mice ... See more keywords
Ascorbate starvation alters endoplasmic reticulum-resident enzymes in cardiac fibroblasts, priming them for increased procollagen secretion.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.09.005
Abstract: Since ascorbate is unnecessary for cell growth and survival, cardiac fibroblasts are routinely cultured without it. However, ascorbate is necessary for optimal collagen synthesis, so we hypothesized that its presence would influence cell phenotype. Cardiac… read more here.
Keywords: ascorbate; secretion; endoplasmic reticulum; cardiac fibroblasts ... See more keywords