Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice
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DOI: 10.1016/j.neurobiolaging.2018.08.002
Abstract: Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by astrocytes during glutamate clearance and disruption of this exchange mechanism may… read more here.
Keywords: ascorbate; ascorbate deficient; mice; deficient mice ... See more keywords