High-Throughput Screening Identifies Ascorbyl Palmitate As a SIRT2 Deacetylase and Defatty-Acylase Inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100343
Abstract: Small molecule inhibitors of SIRT2 are being developed because of their therapeutic potential in a variety of diseases. Here, we developed a high-throughput screen to identify novel SIRT2 inhibitors using a fluorescent SIRT2 probe, 1-aminoanthracene… read more here.
Keywords: defatty acylase; ascorbyl palmitate; deacetylase defatty; sirt2 ... See more keywords
Enhanced antioxidant properties of tara (Caesalpinia spinosa) gallotannins by thermal hydrolysis and its synergistic effects with α‐tocopherol, ascorbyl palmitate, and citric acid on sacha inchi (Plukenetia volubilis) oil
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Food Process Engineering"
DOI: 10.1111/jfpe.12613
Abstract: The antioxidant potential of thermally hydrolyzed tara pod extracts (HTEs) at 121 °C, 103 kPa for different time were tested against sacha inchi oil (SIO) oxidation. The antioxidant efficacy on SIO of 200–400 ppm HTE for… read more here.
Keywords: citric acid; sacha inchi; ascorbyl palmitate; thermal hydrolysis ... See more keywords
Reduction of double chin without surgery using ascorbic acid and ascorbyl-palmitate solution: a clinical study.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202304_31327
Abstract: OBJECTIVE The purpose of the present clinical study is to assess the effectiveness of a lipolytic solution containing sodium salt of ascorbic acid at 0.24% and a surfactant agent at 0.020% ascorbyl-palmitate (SAP) for the… read more here.
Keywords: solution; double chin; ascorbyl palmitate; clinical study ... See more keywords
Enzymatic Synthesis of Ascorbyl Palmitate in a Rotating Bed Reactor
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DOI: 10.3390/molecules28020644
Abstract: Ascorbyl palmitate, an ascorbic acid ester, is an important amphipathic antioxidant that has several applications in foods, pharmaceuticals, and cosmetics. The enzymatic synthesis of ascorbyl palmitate is very attractive, but few efforts have been made… read more here.
Keywords: reactor; synthesis; enzymatic synthesis; ascorbyl palmitate ... See more keywords
Topical Application of Trisodium Ascorbyl 6-Palmitate 2-Phosphate Actively Supplies Ascorbate to Skin Cells in an Ascorbate Transporter-Independent Manner
Sign Up to like & getrecommendations! Published in 2017 at "Nutrients"
DOI: 10.3390/nu9070645
Abstract: Ascorbic acid (AA) possesses multiple beneficial functions, such as regulating collagen biosynthesis and redox balance in the skin. AA derivatives have been developed to overcome this compound’s high fragility and to assist with AA supplementation… read more here.
Keywords: independent manner; ascorbyl palmitate; palmitate phosphate; skin cells ... See more keywords
Ascorbyl Palmitate Hydrogel for Local, Intestinal Delivery of Macromolecules
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DOI: 10.3390/pharmaceutics10040188
Abstract: Biologics have changed the management of inflammatory bowel disease (IBD), but there are concerns with unexpected systemic toxicity and loss of therapeutic response following administration by injection. Rectal administration of biologics offers potentially reduced therapy… read more here.
Keywords: ascorbyl palmitate; hydrogel; delivery; delivery macromolecules ... See more keywords
Synthesis and In Vitro Characterization of Ascorbyl Palmitate-Loaded Solid Lipid Nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14091751
Abstract: Antitumor applications of ascorbic acid (AA) and its oxidized form dehydroascorbic acid (DHA) can be quite challenging due to their instability and sensitivity to degradation in aqueous media. To overcome this obstacle, we have synthesized… read more here.
Keywords: solid lipid; synthesis vitro; sln; ascorbyl palmitate ... See more keywords