Allogeneic adipose‐derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.20-0455
Abstract: Acute radiation syndrome (ARS) is the radiation toxicity that can affect the hematopoietic, gastrointestinal, and nervous systems upon accidental radiation exposure within a short time. Currently, there are no effective and safe approaches to treat… read more here.
Keywords: ascs; bone; bone marrow; marrow cells ... See more keywords
Immunological Tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1007/978-1-4939-8938-6
Abstract: Recently, adipose-derived stem cells (ASCs), obtained from fresh human lipoaspirate, have shown promise as immunomodulatory agents having demonstrated immunosuppressive functionality both in vitro and in vivo. A number of researchers have described the isolation of… read more here.
Keywords: ascs; immunological tolerance;
Adipose-Derived Stem Cells Ameliorate Experimental Murine Colitis via TSP-1-Dependent Activation of Latent TGF-β
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4578-y
Abstract: BackgroundAdipose tissue-derived stem cells (ASCs) have been investigated as therapeutic tools for a variety of autoimmune diseases, including inflammatory diseases. However, the mechanisms underlying the immunomodulatory properties of ASCs are not well understood. Here, we… read more here.
Keywords: latent tgf; activation latent; ascs; colitis ... See more keywords
Multi-layer pre-vascularized magnetic cell sheets for bone regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119664
Abstract: The lack of effective strategies to produce vascularized 3D bone transplants in vitro, hampers the development of thick-constructed bone, limiting the translational of lab-based engineered system to clinical practices. Cell sheet (CS) engineering techniques provide… read more here.
Keywords: vascularized magnetic; pre vascularized; ascs; multi layer ... See more keywords
Modular cell-assembled adipose matrix-derived bead foams as a mesenchymal stromal cell delivery platform for soft tissue regeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120978
Abstract: With the goal of establishing a new clinically-relevant bioscaffold format to enable the delivery of high densities of human adipose-derived stromal cells (ASCs) for applications in soft tissue regeneration, a novel "cell-assembly" method was developed… read more here.
Keywords: ascs; cell assembled; tissue; platform ... See more keywords
ASCs activate cGAS-type I IFNs-IL-7 axis via Pseudomonas aeruginosa-derived outer membrane vesicles to resolve pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells"
DOI: 10.1093/stmcls/sxad016
Abstract: Mesenchymal stem cells (MSCs) therapy could efficiently attenuate LPS-induced acute lung injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the underlying molecular mechanisms are still elusive. Here, we report that PA-derived outer membrane vesicles (OMVs)… read more here.
Keywords: derived outer; pneumonia; pseudomonas aeruginosa; ascs ... See more keywords
It takes a sec(22b) to accrue plasma cells
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12629
Abstract: Antibody-secreting plasma cells (ASCs) protect from infection by secreting pathogen-specific antibodies (Abs). As Abs have a typical half-life of days to weeks, underpinning longterm humoral immunity is the requirement for longevity of ASCs and their… read more here.
Keywords: role; ascs; secretion; sec22b ... See more keywords
P119 Local administered adipose-derived mesenchymal stromal cells reduce experimental oa-pathology via interleukin-1Β-mediated immunomodulation of pro-inflammatory PMNS
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2018.134
Abstract: Introduction Adipose-derived mesenchymal stromal cells (ASCs) exhibit anti-inflammatory characteristics and reduce development of joint pathology after injection into murine experimental inflammatory osteoarthritis (CiOA) joints.1,2 This protection is only achieved when ASCs are applied in early… read more here.
Keywords: mesenchymal stromal; derived mesenchymal; ascs; pathology ... See more keywords
Transmissible Endoplasmic Reticulum Stress Mediated by Extracellular Vesicles from Adipocyte Promoting the Senescence of Adipose-Derived Mesenchymal Stem Cells in Hypertrophic Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7175027
Abstract: Hypertrophic obesity, characterized by an excessive expansion of subcutaneous adipocytes, causes chronic inflammation and insulin resistance. It is the primary feature of obesity in middle-aged and elderly individuals. In the adipose microenvironment, a high level… read more here.
Keywords: stress; ascs; hypertrophic obesity; senescence ... See more keywords
Matrix Metalloproteases from Adipose Tissue-Derived Stromal Cells Are Spatiotemporally Regulated by Hydrogel Mechanics in a 3D Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9080340
Abstract: Adipose tissue-derived stromal cells (ASCs) are of interest in tissue engineering and regenerative medicine (TERM) due to their easy acquisition, multipotency, and secretion of a host of factors that promote regeneration. Retention of ASCs in… read more here.
Keywords: derived stromal; tissue derived; ascs; adipose tissue ... See more keywords
Impact of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Rheumatic Disease Patients on T Helper Cell Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105317
Abstract: Complex pathogenesis of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) is associated with an imbalance of various Th-cell subpopulations. Mesenchymal stem cells (MSCs) have the ability to restore this balance. However, bone marrow-derived MSCs… read more here.
Keywords: cell; ascs; mesenchymal stem; differentiation ... See more keywords