Targeting ASCT2-mediated glutamine metabolism inhibits proliferation and promotes apoptosis of pancreatic cancer cells
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DOI: 10.1042/bsr20212171
Abstract: Abstract Some tumor cells have a high rate of glutamine uptake and exhibit glutamine addiction. Alanine-serine cysteine-preferring transporter 2 (ASCT2) is a major mediator of glutamine supply in many tumor cells, but the underlying effects… read more here.
Keywords: pancreatic cancer; asct2; glutamine metabolism; expression ... See more keywords
Conserved allosteric inhibition mechanism in SLC1 transporters
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DOI: 10.1101/2022.09.21.508810
Abstract: Excitatory Amino Acid Transporter 1 (EAAT1) is a plasma-membrane glutamate transporter belonging to the SLC1 family of solute carriers. It plays a key role in neurotransmitter transport and contributes to the regulation of the extracellular… read more here.
Keywords: asct2; f136y i237m; transporter; mechanism ... See more keywords
Second Autologous Stem Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma after a Previous Autograft: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation
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DOI: 10.1182/blood-2018-99-112180
Abstract: Patients with relapsed or refractory (R/R) Hodgkin Lymphoma (HL) after first autologous stem cell transplantation (ASCT1) may be offered several therapeutic options. New agents such as brentuximab vedotin or checkpoint inhibitors have recently been approved… read more here.
Keywords: year; cell transplantation; stem cell; transplantation ... See more keywords
Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.871392
Abstract: Metabolic reprogramming is considered to be a hallmark of cancer, and increased glutamine metabolism plays an important role in the progression of many tumors, including colorectal cancer (CRC). Targeting of glutamine uptake via the transporter… read more here.
Keywords: anti tumor; cancer; asct2; colorectal cancer ... See more keywords
Cysteine 467 of the ASCT2 Amino Acid Transporter Is a Molecular Determinant of the Antiport Mechanism
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DOI: 10.3390/ijms23031127
Abstract: The plasma membrane transporter ASCT2 is a well-known Na+-dependent obligatory antiporter of neutral amino acids. The crucial role of the residue C467 in the recognition and binding of the ASCT2 substrate glutamine, has been highlighted… read more here.
Keywords: 467 asct2; asct2; transporter; cysteine 467 ... See more keywords