Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3‐EDT2
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DOI: 10.1002/cbic.201700253
Abstract: Methods for activating signaling enzymes hold significant potential for the study of cellular signal transduction. Here we present a strategy for engineering chemically activatable protein tyrosine phosphatases (actPTPs). To generate actPTP1B, we introduced three cysteine… read more here.
Keywords: tyrosine phosphatases; ascy3 edt2; wpd loop; protein tyrosine ... See more keywords