Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.03.009
Abstract: Individuals with germline PTEN tumor-suppressor variants have PTEN hamartoma tumor syndrome (PHTS). Clinically, PHTS has variable presentations; there are distinct subsets of PHTS-affected individuals, such as those diagnosed with autism spectrum disorder (ASD) or cancer.… read more here.
Keywords: allosteric regulation; structural communication; cancer; asd cancer ... See more keywords
Deep learning enabled integration of tumor microenvironment microbial profiles and host gene expressions for interpretable survival subtyping in diverse types of cancers
Sign Up to like & getrecommendations! Published in 2024 at "mSystems"
DOI: 10.1128/msystems.01395-24
Abstract: ABSTRACT The tumor microbiome, a complex community of microbes found in tumors, has been found to be linked to cancer development, progression, and treatment outcome. However, it remains a bottleneck in distangling the relationship between… read more here.
Keywords: cancer; asd cancer; host gene; tumor microenvironment ... See more keywords