Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.
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DOI: 10.1016/j.ajhg.2019.03.009
Abstract: Individuals with germline PTEN tumor-suppressor variants have PTEN hamartoma tumor syndrome (PHTS). Clinically, PHTS has variable presentations; there are distinct subsets of PHTS-affected individuals, such as those diagnosed with autism spectrum disorder (ASD) or cancer.… read more here.
Keywords: allosteric regulation; structural communication; cancer; asd cancer ... See more keywords