Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted.
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DOI: 10.1021/acs.molpharmaceut.3c00008
Abstract: Amorphous solid dispersions (ASDs) are commonly used to increase the dissolution rate of poorly soluble active pharmaceutical ingredients (APIs). Unfortunately, most ASDs are thermodynamically unstable and, even though kinetically stabilized, will thus eventually crystallize. The… read more here.
Keywords: glassy asds; asds; supercooled glassy; behavior supercooled ... See more keywords
Impact of HPMCAS on the Dissolution Performance of Polyvinyl Alcohol Celecoxib Amorphous Solid Dispersions
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DOI: 10.3390/pharmaceutics12060541
Abstract: Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a sufficient stabilization of the generated supersaturation. In… read more here.
Keywords: solid dispersions; amorphous solid; asds; polyvinyl alcohol ... See more keywords