Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00008
Abstract: Amorphous solid dispersions (ASDs) are commonly used to increase the dissolution rate of poorly soluble active pharmaceutical ingredients (APIs). Unfortunately, most ASDs are thermodynamically unstable and, even though kinetically stabilized, will thus eventually crystallize. The… read more here.
Keywords: glassy asds; asds; supercooled glassy; behavior supercooled ... See more keywords
Amorphous Solid Dispersion Formation for Enhanced Release Performance of Racemic and Enantiopure Praziquantel
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c00711
Abstract: Praziquantel (PZQ) is the treatment of choice for schistosomiasis, which affects more than 250 million people globally. Commercial tablets contain the crystalline racemic compound (RS-PZQ) which limits drug dissolution and oral bioavailability and can lead… read more here.
Keywords: amorphous solid; release; pzq; asds ... See more keywords
Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations
Sign Up to like & getrecommendations! Published in 2024 at "Brain Sciences"
DOI: 10.3390/brainsci14050454
Abstract: The roles of perinatal development, intracellular calcium [Ca2+]i, and synaptogenesis disruption are not novel in the autism/ASD literature. The focus on six mechanisms controlling synaptogenesis, each regulated by [Ca2+]i, and each aberrant in ASDs is… read more here.
Keywords: six mechanisms; synaptogenesis; causation; asds ... See more keywords
Impact of HPMCAS on the Dissolution Performance of Polyvinyl Alcohol Celecoxib Amorphous Solid Dispersions
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12060541
Abstract: Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a sufficient stabilization of the generated supersaturation. In… read more here.
Keywords: solid dispersions; amorphous solid; asds; polyvinyl alcohol ... See more keywords