Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Bone Reports"
DOI: 10.1016/j.bonr.2021.101163
Abstract: Hypophosphatasia (HPP) is a congenital disorder with decreased activity of tissue-nonspecific alkaline phosphatase. Asfotase alfa is the only treatment approved for HPP and improves the impairment of bone mineralization. Although several previous studies have reported… read more here.
Keywords: benign prenatal; case report; asfotase alfa; pseudofracture ... See more keywords
Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia.
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DOI: 10.1016/j.pediatrneurol.2021.12.009
Abstract: BACKGROUND Hypophosphatasia (HPP), an inherited, metabolic disorder caused by loss-of-function mutations in the ALPL gene, affects not only bone and tooth mineralization but also central nervous system (CNS) function, resulting in vitamin B6/pyridoxine-responsive seizures. Asfotase… read more here.
Keywords: asfotase alfa; asfotase; seizure exacerbation; interruption ... See more keywords
Effect of Asfotase Alfa on Muscle Weakness in a Japanese Adult Patient of Hypophosphatasia with Low ALP Levels
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DOI: 10.2169/internalmedicine.3298-19
Abstract: A 40-year-old Japanese woman presented to our hospital with general fatigue and muscle weakness. She had a history of premature loss of deciduous teeth at 4 years old, her serum alkaline phosphatase (ALP) activity was… read more here.
Keywords: asfotase alfa; asfotase; muscle weakness;