Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors.
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DOI: 10.1021/acs.jmedchem.4c01673
Abstract: The absent, small, or homeotic-like 1 (ASH1L) protein is a histone lysine methyltransferase that plays a crucial role in various cancers, including leukemia. Despite representing an attractive therapeutic target, only one class of ASH1L inhibitors… read more here.
Keywords: ash1l; chemistry; structure based; ash1l inhibitors ... See more keywords
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation
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DOI: 10.1038/s41467-025-57556-5
Abstract: The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal region of ASH1L encompassing a… read more here.
Keywords: ash1l; histone h3k36; structure function; h3k36 ... See more keywords
Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression
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DOI: 10.3748/wjg.v31.i1.101198
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) has been a pervasive malignancy throughout the world with elevated mortality. Efficient therapeutic targets are beneficial to treat and predict the disease. Currently, the exact molecular mechanisms leading to the progression… read more here.
Keywords: ash1l; microrna 142; progression; hcc ... See more keywords