Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-017-1416-0
Abstract: The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations… read more here.
Keywords: application nudt15; bowel disease; inflammatory bowel; asian populations ... See more keywords
Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes Therapy"
DOI: 10.1007/s13300-017-0322-z
Abstract: Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin—an issue which needs to be further examined. Here we review the… read more here.
Keywords: insulin; titration; asian populations; titration basal ... See more keywords
Molecular analysis of haemoglobin E in Southeast Asian populations
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Human Biology"
DOI: 10.1080/03014460.2017.1388844
Abstract: Abstract Haemoglobin (Hb) E is the most common Hb variant in Asia where its gene frequency approaches 0.3 in some areas. We studied genetic background of Hb E genes among Southeast Asian populations. This study… read more here.
Keywords: southeast asian; asian populations; molecular analysis; analysis haemoglobin ... See more keywords
The diagnostic value of glycosylated hemoglobin for gestational diabetes mellitus in Asian populations: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15170
Abstract: To investigate the role of glycosylated hemoglobin in assisting the oral glucose tolerance test for gestational diabetes mellitus (GDM) diagnosis in Asian populations. read more here.
Keywords: value glycosylated; asian populations; glycosylated hemoglobin; diabetes mellitus ... See more keywords
Genetic Analysis of LRRK2 R1628P in Parkinson's Disease in Asian Populations
Sign Up to like & getrecommendations! Published in 2017 at "Parkinson's Disease"
DOI: 10.1155/2017/8093124
Abstract: Although the etiology of Parkinson's disease (PD) remains unclear, there is increasing evidence of genetic factors contributing to the onset of PD. Various mutations and risk variants of the gene LRRK2 have been reported, but… read more here.
Keywords: lrrk2 r1628p; asian populations; r1628p; parkinson disease ... See more keywords
Integrative Genomic Profiling Uncovers Therapeutic Targets of Acral Melanoma in Asian Populations
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-3344
Abstract: Abstract Purpose: Acral melanoma is the major subtype of melanoma seen in Asian patients with melanoma and is featured by its insidious onset and poor prognosis. The genomic study that elucidates driving mutational events is… read more here.
Keywords: melanoma; melanoma asian; acral melanoma; asian populations ... See more keywords
BIN1 rs744373 variant shows different association with Alzheimer’s disease in Caucasian and Asian populations
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3264-9
Abstract: The association between BIN1 rs744373 variant and Alzheimer’s disease (AD) had been identified by genome-wide association studies (GWASs) as well as candidate gene studies in Caucasian populations. But in East Asian populations, both positive and… read more here.
Keywords: analysis; asian populations; association; rs744373 variant ... See more keywords
The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9100570
Abstract: This meta-analysis aimed to systematically review the evidence on cancer risk of the MMP-8 rs11225395 promoter polymorphism. Relevant studies published by 12 June 2019 were identified by systematically searching PubMed, Web of Science, Cochrane Library,… read more here.
Keywords: asian populations; cancer risk; mmp rs11225395; cancer ... See more keywords
Relevance of CYP2D6 Gene Variants in Population Genetic Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112481
Abstract: A significant portion of the variability in complex features, such as drug response, is likely caused by human genetic diversity. One of the highly polymorphic pharmacogenes is CYP2D6, encoding an enzyme involved in the metabolism… read more here.
Keywords: cyp2d6 gene; populations form; cyp2d6; african populations ... See more keywords
Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology and metabolism"
DOI: 10.3803/enm.2020.772
Abstract: Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity-the "skinny-fat" Asian syndrome. In this review, we critically… read more here.
Keywords: environmental factors; asian populations; visceral adiposity; adiposity asian ... See more keywords