Geographic atrophy in Asia
Sign Up to like & getrecommendations! Published in 2025 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-025-06817-6
Abstract: Geographic atrophy (GA) is a late-stage manifestation of age-related macular degeneration associated with vision loss. Differences between Asian and non-Asian populations with GA have been reported. It is essential to understand these differences because they… read more here.
Keywords: geographic atrophy; asian populations; asian non; non asian ... See more keywords
Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-017-1416-0
Abstract: The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations… read more here.
Keywords: application nudt15; bowel disease; inflammatory bowel; asian populations ... See more keywords
Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes Therapy"
DOI: 10.1007/s13300-017-0322-z
Abstract: Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin—an issue which needs to be further examined. Here we review the… read more here.
Keywords: insulin; titration; asian populations; titration basal ... See more keywords
SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-55147-4
Abstract: Limited whole genome sequencing (WGS) studies in Asian populations result in a lack of representative reference panels, thus hindering the discovery of ancestry-specific variants. Here, we present the South and East Asian reference Database (SEAD)… read more here.
Keywords: panel; asian populations; reference; genome ... See more keywords
Imputation disparities driven by recent selection and their impact on disease risk estimation in East and Southeast Asian populations.
Sign Up to like & getrecommendations! Published in 2025 at "Communications biology"
DOI: 10.1038/s42003-025-09214-1
Abstract: Accurate genotype imputation is essential for large-scale genetic studies and precision medicine. While East Asian (EAS)-specific reference panels like ChinaMAP and CHN100k have been developed, most studies still rely on multi-ancestry panels like TOPMed due… read more here.
Keywords: asian populations; east southeast; reference panels; imputation ... See more keywords
Molecular analysis of haemoglobin E in Southeast Asian populations
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Human Biology"
DOI: 10.1080/03014460.2017.1388844
Abstract: Abstract Haemoglobin (Hb) E is the most common Hb variant in Asia where its gene frequency approaches 0.3 in some areas. We studied genetic background of Hb E genes among Southeast Asian populations. This study… read more here.
Keywords: southeast asian; asian populations; molecular analysis; analysis haemoglobin ... See more keywords
A Mendelian randomization study of serum uric acid in metabolic and cardiovascular risk in East Asian populations
Sign Up to like & getrecommendations! Published in 2025 at "Medicine"
DOI: 10.1097/md.0000000000044135
Abstract: Serum uric acid (SUA) levels are linked to increased disease vulnerability and higher recurrence rates; however, the exact causal relationships are elusive. Despite the prevalent hyperuricemia in East Asian populations, comprehensive research on the intricate… read more here.
Keywords: asian populations; risk; serum uric; east asian ... See more keywords
The diagnostic value of glycosylated hemoglobin for gestational diabetes mellitus in Asian populations: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15170
Abstract: To investigate the role of glycosylated hemoglobin in assisting the oral glucose tolerance test for gestational diabetes mellitus (GDM) diagnosis in Asian populations. read more here.
Keywords: value glycosylated; asian populations; glycosylated hemoglobin; diabetes mellitus ... See more keywords
Genetic Analysis of LRRK2 R1628P in Parkinson's Disease in Asian Populations
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DOI: 10.1155/2017/8093124
Abstract: Although the etiology of Parkinson's disease (PD) remains unclear, there is increasing evidence of genetic factors contributing to the onset of PD. Various mutations and risk variants of the gene LRRK2 have been reported, but… read more here.
Keywords: lrrk2 r1628p; asian populations; r1628p; parkinson disease ... See more keywords
Integrative Genomic Profiling Uncovers Therapeutic Targets of Acral Melanoma in Asian Populations
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-3344
Abstract: Abstract Purpose: Acral melanoma is the major subtype of melanoma seen in Asian patients with melanoma and is featured by its insidious onset and poor prognosis. The genomic study that elucidates driving mutational events is… read more here.
Keywords: melanoma; melanoma asian; acral melanoma; asian populations ... See more keywords
BIN1 rs744373 variant shows different association with Alzheimer’s disease in Caucasian and Asian populations
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3264-9
Abstract: The association between BIN1 rs744373 variant and Alzheimer’s disease (AD) had been identified by genome-wide association studies (GWASs) as well as candidate gene studies in Caucasian populations. But in East Asian populations, both positive and… read more here.
Keywords: analysis; asian populations; association; rs744373 variant ... See more keywords