Pharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis
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DOI: 10.1007/s00228-017-2217-3
Abstract: PurposeEmerging data on selumetinib, a MEK1/2 inhibitor in clinical development, suggest a possible difference in pharmacokinetics (PK) between Japanese and Western patients. This pooled analysis sought to assess the effect of ethnicity on selumetinib exposure… read more here.
Keywords: selumetinib; analysis; mek1 inhibitor; asian subjects ... See more keywords
Revisiting the steatosis‐associated fibrosis estimator score in young Asian subjects with steatotic liver disease and consideration for population variability
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DOI: 10.1111/jgh.16656
Abstract: The steatosis‐associated fibrosis estimator (SAFE) score has been developed to distinguish clinically significant fibrosis in patients with steatotic liver disease (SLD). However, validation of its performance in Asian subjects is limited. This study aimed to… read more here.
Keywords: associated fibrosis; steatosis associated; fibrosis; asian subjects ... See more keywords