Synthesis of asiatic acid derivatives and their cytotoxic activity
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2176-y
Abstract: Twenty-eight compounds, including 24 new (4–22, 25–26, and 28–30) and four known (2, 23, 24, and 27) have been synthesized starting from asiatic acid (1), which was isolated from Centella asiatica. The preparation procedure included… read more here.
Keywords: cell lines; synthesis asiatic; asiatic acid; cell ... See more keywords
Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Calcified Tissue International"
DOI: 10.1007/s00223-019-00596-z
Abstract: Anti-resorptive agents like bisphosphonates have been widely used for the treatment of postmenopausal osteoporosis. However, their long-term safety and efficacy are still controversial. This study is to examine the effect of Asiatic acid (AA) in… read more here.
Keywords: osteoclastic differentiation; differentiation; bone loss; asiatic acid ... See more keywords
Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague–Dawley rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3199-2
Abstract: The present study evaluated the effects of asiatic acid (AA), a pentacyclic triterpenoid from Centella asiatica on lipid metabolism parameters in a rat model of obesity induced using a high fat diet (HFD) for 42 days.… read more here.
Keywords: fat diet; cpt1 mrna; high fat; expression ... See more keywords
Transformation of asiatic acid into a mitocanic, bimodal-acting rhodamine B conjugate of nanomolar cytotoxicity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.066
Abstract: Based on their biological activity natural products continue to represent optimal lead structures for the development of novel drug candidates. We focused on the syntheses of several derivatives of the triterpene asiatic acid and on… read more here.
Keywords: cytotoxicity; rhodamine conjugate; asiatic acid;
Oxidative stress and hepatocellular mitochondrial dysfunction attenuated by asiatic acid in streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of King Saud University - Science"
DOI: 10.1016/j.jksus.2021.101369
Abstract: Abstract Oxidative stress produced by mitochondria is one of the main causes for diabetes associated complications. This study was planned to assess the efficacy of asiatic acid (AA) on oxidative stress mediated hepatocellular mitochondrial dysfunction… read more here.
Keywords: mitochondrial dysfunction; hepatocellular mitochondrial; diabetic rats; asiatic acid ... See more keywords
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119567
Abstract: AIM This study aimed to evaluate the effects of Asiatic acid (AA), a naturally occurring compound of pentacyclic triterpenoid, on the pathological processes of diabetic retinopathy (DR). METHODS SD rats were induced to develop early… read more here.
Keywords: myd88 p65; diabetic retinopathy; tlr4 myd88; polarization ... See more keywords
Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.01.022
Abstract: Accumulating evidence indicates that asiatic acid, a natural triterpene isolated from Centella asiatica, has anti-inflammatory activity. However, the anti-inflammatory effects of asiatic acid on LPS-stimulated endometrial epithelial cells and the involved molecular pathways have not… read more here.
Keywords: epithelial cells; lps induced; endometrial epithelial; asiatic acid ... See more keywords
Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.08.005
Abstract: Endothelial hyperpermeability represents an initiating step in early atherosclerosis and it often occurs as a result of endothelial barrier dysfunction. Asiatic acid, a major triterpene isolated from Centella asiatica (L.) Urban, has previously been demonstrated… read more here.
Keywords: tnf induced; aortic endothelial; asiatic acid; acid ... See more keywords
Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2048849
Abstract: Abstract Background: Psoriasis is a common skin disorder related to inflammation and immune response. However, many treatment modalities are present in the clinics, and drug conformity halts chronic treatment. Therefore, novel treatment options are still… read more here.
Keywords: imiquimod induced; acid; asiatic acid; induced psoriasis ... See more keywords
Synthesis and anti-tumor activity of derivatives of ring A of asiatic acid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1616693
Abstract: Abstract Based on the simulation of the docking of survivin protein with known small molecule inhibitors, the active groups which can bind to target proteins were analyzed by the techniques of computer-aided drug design (CADD).… read more here.
Keywords: ring asiatic; tumor activity; anti tumor; synthesis anti ... See more keywords
Synthesis and anti-tumor activity of asiatic acid derivatives targeting VEGFR.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2202855
Abstract: To discovery novel VEGFR inhibitors, 12 novel asiatic acid derivatives were designed by computer-aided drug design (CADD) technology. Then, these novel asiatic acid derivatives were synthesized by introducing active groups at ring A and C-28… read more here.
Keywords: anti tumor; novel asiatic; acid; asiatic acid ... See more keywords