Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.
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DOI: 10.1021/acs.jmedchem.1c00305
Abstract: Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca2+ ions, listed among putative targets in central nervous system (CNS) diseases in which a pH modification occurs. We targeted novel compounds able to modulate… read more here.
Keywords: mono bis; asic1; bis guanyl; guanyl hydrazones ... See more keywords