Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1289-0
Abstract: Tissue acidosis is a common feature of brain ischemia which causes neuronal injury. Activation of acid-sensing ion channel 1a (ASIC1a) plays an important role in acidosis-mediated neurotoxicity. Acute ethanol administration has been shown to provide… read more here.
Keywords: acidosis; asic1a; induced neurotoxicity; acidosis induced ... See more keywords
RIP3 Mediates Necroptotic Cell Death in Response to Acid Stimulation of ASIC1a
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2958
Abstract: Acidosis occurs commonly under pathological conditions when body homeostasis is disrupted due to inflammation, hypoxia, cancer and other illnesses. However, the effects of acidosis on cell fates differ dramatically from one cell type to another.… read more here.
Keywords: acidosis; asic1a; rip3; cell death ... See more keywords
Acid-Sensing Ion Channel 1a Modulates NMDA Receptor Function Through Targeting NR1/NR2A/NR2B Triheteromeric Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.03.044
Abstract: The over-activation of N-methyl-D-aspartate receptors (NMDARs) is the main cause of neuronal death in brain ischemia. Both the NMDAR and the Acid-sensing ion channel 1a (ASIC1a) are present in the postsynaptic membrane of the central… read more here.
Keywords: sensing ion; nr1 nr2a; asic1a; ion channel ... See more keywords
ASIC1a involves acidic microenvironment-induced activation and autophagy of pancreatic stellate cells
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra03679a
Abstract: Acid-sensing ion channel 1a (ASIC1a), as a member of the proton-gated cation channel family, can be activated by low extracellular pH, and takes part in many acidity-associated physiopathological processes. However, whether ASIC1a is expressed in… read more here.
Keywords: activation autophagy; pscs; asic1a; pancreatic stellate ... See more keywords
Genetic or pharmacological ablation of ASIC1a is not neuroprotective in a mouse model of spinal cord injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0295
Abstract: Acid sensing ion channel 1a (ASIC1a) is a proton-activated channel that is expressed ubiquitously throughout the central nervous system and in various types of immune cells. Its role in spinal cord injury (SCI) is controversial;… read more here.
Keywords: cord; cord injury; ablation; asic1a ... See more keywords
Deletion of the Acid-Sensing Ion Channel 1a Gene Leads to Age-Related Hypertension in Male but not Female Mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5791746
Abstract: Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that conducts both Na+ and Ca2+ in the cell. Studies have shown that ASIC1a is expressed in smooth muscle and endothelial cells of various vascular… read more here.
Keywords: female mice; hypertension; age; physiology ... See more keywords
ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway
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DOI: 10.18632/oncotarget.14164
Abstract: In neurons, up-regulation of Notch activity either inhibits neurite extension or causes retraction of neurites. Conversely, inhibition of Notch1 facilitates neurite extension. Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels, which play… read more here.
Keywords: asic1a; notch; neurite growth; notch signaling ... See more keywords
Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s376979
Abstract: Background The ketogenic diet (KD) is a proven therapy for refractory epilepsy. Although the anti-seizure properties of this diet are understood to a certain extent, the exploration of its neuroprotective effects and underlying mechanisms is… read more here.
Keywords: model temporal; via asic1a; rat model; asic1a ... See more keywords
ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological research"
DOI: 10.33549/physiolres.934950
Abstract: The acidic tumor microenvironment (TME) of pancreatic cancer affects the physiological function of pancreatic stellate cells (PSCs), which in turn promotes cancer progression. Acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-related physiopathological processes. In… read more here.
Keywords: stellate cells; pancreatic stellate; associated autophagy; asic1a involves ... See more keywords
Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.989809
Abstract: Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in multiple cell types, including… read more here.
Keywords: pulmonary hypertension; asic1a; mice; induced pulmonary ... See more keywords
Signaling Pathways in Proton and Non-proton ASIC1a Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.735414
Abstract: Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases as well as pain conditions. Classically, ASICs are described as transiently activated by a reduced pH, followed by desensitization; the activation… read more here.
Keywords: signaling pathways; asic1a; proton; activation ... See more keywords