Perilla frutescens L. alleviates trimethylamine N‐oxide–induced apoptosis in the renal tubule by regulating ASK1‐JNK phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7684
Abstract: Trimethylamine N‐oxide (TMAO) is associated with overall mortality in patients with chronic kidney disease (CKD). Previous findings suggest that P. frutescens (L.) can alleviate renal injury, but its effects and mechanisms underlying alleviation of TMAO‐induced… read more here.
Keywords: apoptosis; jnk phosphorylation; jnk; tmao ... See more keywords
LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway
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DOI: 10.1080/08923973.2022.2078728
Abstract: Abstract Objectives This study aimed to explore the underlying role and mechanism of LINC00313 in osteoarthritis (OA) progression. Methods CHON-001 chondrocytes were treated with interleukin (IL)-1β to induce OA in vitro, and then transfected with… read more here.
Keywords: signaling pathway; promoter methylation; jnk signaling; jnk ... See more keywords
Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways
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DOI: 10.3389/fncel.2019.00190
Abstract: Objective As a high-level nerve center that regulates visceral and endocrine activity, the hypothalamus plays an important role in regulating the body’s stress response. Previous studies have shown that stress can cause damage to hypothalamic… read more here.
Keywords: hypothalamic neurons; jnk; ask1 jnk; stress ... See more keywords