Acid sphingomyelinase (ASM) and COVID‐19: A review of the potential use of ASM inhibitors against SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3789
Abstract: In the last 2 years, different pharmacological agents have been indicated as potential inhibitors of SARS‐CoV‐2 in vitro. Specifically, drugs termed as functional inhibitors of acid sphingomyelinase (FIASMAs) have proved to inhibit the SARS‐CoV‐2 replication… read more here.
Keywords: inhibitors sars; review; asm; sphingomyelinase asm ... See more keywords
Glial-derived neurotrophic factor in human airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30489
Abstract: Airway smooth muscle (ASM) cells modulate the local airway milieu via production of inflammatory mediators and growth factors including classical neurotrophins, such as brain-derived neurotrophic factor (BDNF). The glial cell-derived neurotrophic factor (GDNF) family of… read more here.
Keywords: derived neurotrophic; asm; smooth muscle; neurotrophic factor ... See more keywords
A 17 ka multi‐proxy paleoclimatic record on the northeastern Tibetan Plateau: implications for the northernmost boundary of the Asian summer monsoon during the Holocene
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Climatology"
DOI: 10.1002/joc.7239
Abstract: Knowledge of the paleoclimatic record of the northeastern Tibetan Plateau (NETP) can potentially improve our understanding of the evolution of the Asian summer monsoon (ASM). However, the history of climate change and inferred spatial extent… read more here.
Keywords: monsoon; hala lake; deglaciation; asm ... See more keywords
Can GPCRs Be Targeted to Control Inflammation in Asthma?
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-68748-9_1
Abstract: Historically, the drugs used to manage obstructive lung diseases (OLDs), asthma, and chronic obstructive pulmonary disease (COPD) either (1) directly regulate airway contraction by blocking or relaxing airway smooth muscle (ASM) contraction or (2) indirectly… read more here.
Keywords: asm; gpcrs targeted; asm contraction; inflammation ... See more keywords
Automated Self-management (ASM) vs. ASM-Enhanced Collaborative Care for Chronic Pain and Mood Symptoms: the CAMMPS Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-019-05121-4
Abstract: Chronic musculoskeletal pain is often accompanied by depression or anxiety wherein co-occurring pain and mood symptoms can be more difficult to treat than either alone. However, few clinical trials have examined interventions that simultaneously target… read more here.
Keywords: asm; pain mood; management; care ... See more keywords
Hybrid method for automatic construction of 3D-ASM image intensity models for left ventricle
Sign Up to like & getrecommendations! Published in 2020 at "Neurocomputing"
DOI: 10.1016/j.neucom.2019.10.102
Abstract: Abstract Active Shape Models (ASMS) play an important role in model based medical image analysis. They utilize point distribution models (PDMs) in which a priori information is encoded into a template so that the objects… read more here.
Keywords: image; asm image; asm; intensity models ... See more keywords
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.09.010
Abstract: Although many reports have revealed dysfunction of endothelial cells in aging, resulting in blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to be explored. Here, we find that acid sphingomyelinase (ASM) is a critical… read more here.
Keywords: asm; aging mice; rejuvenation aging; neurogenic rejuvenation ... See more keywords
Treatment of Neonatal Seizures: Comparison of Treatment Pathways From 11 Neonatal Intensive Care Units.
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2021.10.004
Abstract: OBJECTIVE Seizures are a common neonatal neurologic emergency. Many centers have developed pathways to optimize management. We evaluated neonatal seizure management pathways at level IV neonatal intensive care units (NICUs) in the United States to… read more here.
Keywords: asm; treatment; intensive care; management ... See more keywords
A mixed-method investigations of work, government and social factors associated with severe injuries in artisanal and small-scale mining (ASM) operations
Sign Up to like & getrecommendations! Published in 2021 at "Safety Science"
DOI: 10.1016/j.ssci.2021.105244
Abstract: Abstract The susceptibility of miners to severe injuries in Artisanal and Small-scale Mining (ASM) operations is significantly higher than in the larger-scale mining industry. However, the most prevalent and least studied safety aspects are the… read more here.
Keywords: severe injuries; scale mining; asm; safety ... See more keywords
Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01643
Abstract: Acid sphingomyelinase (ASM), which regulates sphingolipid metabolism and lipid signaling, has been considered as a new potential target for the treatment of atherosclerosis. In this study, a series of benzene-heterocyclic-based ASM inhibitors were rationally designed,… read more here.
Keywords: discovery novel; novel hydroxy; asm; atherosclerosis ... See more keywords
Anthropogenic Aerosols Cause Recent Pronounced Weakening of Asian Summer Monsoon Relative to Last Four Centuries
Sign Up to like & getrecommendations! Published in 2019 at "Geophysical Research Letters"
DOI: 10.1029/2019gl082497
Abstract: The Asian Summer Monsoon (ASM) affects ecosystems, biodiversity, and food security of billions of people. In recent decades, ASM strength (as represented by precipitation) has been decreasing, but instrumental measurements span only a short period… read more here.
Keywords: asian summer; anthropogenic aerosols; summer monsoon; asm ... See more keywords