Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity
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DOI: 10.1158/0008-5472.can-19-1527
Abstract: This study identifies secreted ASM and ceramide as paracrine factors enhancing intestinal epithelial dysfunction, revealing a previously unknown class of mediators of radiosensitivity. Ceramide-induced endothelial cell apoptosis boosts intestinal stem cell radiosensitivity. However, the molecular… read more here.
Keywords: radiation; dysfunction; ceramide; asm ceramide ... See more keywords