Geological characteristics of landslides triggered by the 2016 Kumamoto earthquake in Mt. Aso volcano, Japan
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Engineering Geology and the Environment"
DOI: 10.1007/s10064-017-1097-1
Abstract: On 16 April 2016, a Mw 7.0 earthquake occurred in Kumamoto city, Japan. The main shock induced two large landslides, namely the Aso Bridge landslide and the Aso Volcanological Laboratory landslide. Their topographical and geological… read more here.
Keywords: landslide; aso; direction; kumamoto ... See more keywords
Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02111
Abstract: Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and trafficking mechanisms of ASOs is highly important for early-stage drug discovery.… read more here.
Keywords: quantification oligonucleotide; quantification; intracellular absolute; aso ... See more keywords
Antibacterial FANA oligonucleotides as a novel approach for managing the Huanglongbing pathosystem
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82425-8
Abstract: Candidatus Liberibacter asiaticus (CLas), a bacterium transmitted by the Asian citrus psyllid, Diaphorina citri, is the causal agent of citrus greening disease, or Huanglongbng (HLB). Currently, vector population suppression with insecticides and tree removal are… read more here.
Keywords: aso; pathosystem; fana aso; specific fana ... See more keywords
Abstract B019: ASO-mediated NRAS knockdown overcomes gilteritinib late resistance in FLT3-AML
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b019
Abstract: The internal tandem duplication of the FLT3 receptor (FLT3-ITD) leads to constitutive receptor activation and is one of the most common mutations (~30%) in acute myeloid leukemia (AML), resulting in poor prognosis. Multiple FLT3 inhibitors… read more here.
Keywords: flt3; nras mrna; aso; resistance ... See more keywords
Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248416676392
Abstract: Background: Phospholamban (PLN) inhibition enhances calcium cycling and is a potential novel therapy for heart failure (HF). Antisense oligonucleotides (ASOs) are a promising tool for unmet medical needs. Nonviral vector use of locked nucleic acid… read more here.
Keywords: aso; pressure overload; overload induced; lna aso ... See more keywords
Antisense oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000323
Abstract: There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in medicine. Indeed,… read more here.
Keywords: antisense oligonucleotides; development; aso; disease ... See more keywords
Enhanced Antisense Oligonucleotide Delivery Using Cationic Liposomes Grafted with Trastuzumab: A Proof-of-Concept Study in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12121166
Abstract: Prostate cancer (PCa) is the second most common cancer in men worldwide and the fifth leading cause of death by cancer. The overexpression of TCTP protein plays an important role in castration resistance. Over the… read more here.
Keywords: aso; delivery; prostate cancer; efficacy ... See more keywords