Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
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DOI: 10.1124/dmd.121.000417
Abstract: Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug’s pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs). The chemical structures, dosage forms, and… read more here.
Keywords: distribution metabolism; drug; administration; aso drugs ... See more keywords
Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
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DOI: 10.1124/dmd.121.000418
Abstract: The market for large molecule biologic drugs has grown rapidly, including antisense oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that reduce production or alter functions of disease-causing proteins through various mechanisms, such… read more here.
Keywords: administration; aso drugs; adrs toxicity; approved aso ... See more keywords