Improving the Developability of an Antigen Binding Fragment by Aspartate Substitutions.
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DOI: 10.1021/acs.biochem.9b00251
Abstract: Aggregation can be a major challenge in the development of antibody-based pharmaceuticals as it can compromise the quality of the product during bioprocessing, formulation, and drug administration. To avoid aggregation, developability assessment is often run… read more here.
Keywords: developability; aggregation; antigen binding; asp substitutions ... See more keywords