Genetic predisposition to PEG‐asparaginase hypersensitivity in children treated according to NOPHO ALL2008
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15660
Abstract: Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase (PEG-asparaginase) hampers anti-neoplastic efficacy. Patients with PEG-asparaginase hypersensitivity have been shown to possess zero asparaginase enzyme activity. Using this… read more here.
Keywords: hypersensitivity; asparaginase hypersensitivity; peg asparaginase; enzyme activity ... See more keywords
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2016-0033
Abstract: Abstract Acute lymphoblastic leukemia (ALL) is a major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events.… read more here.
Keywords: lymphoblastic leukemia; asparaginase hypersensitivity; review; acute lymphoblastic ... See more keywords
HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2017.168211
Abstract: Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. The aim of the present study was to identify associations between sequence-based Human Leukocyte Antigen… read more here.
Keywords: risk; hla dqb1; hla; asparaginase hypersensitivity ... See more keywords