Serum metabolomic profile of incident diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4573-7
Abstract: Aims/hypothesisMetabolomic profiling offers the potential to reveal metabolic pathways relevant to the pathophysiology of diabetes and improve diabetes risk prediction.MethodsWe prospectively analysed known metabolites using an untargeted approach in serum specimens from baseline (1987–1989) and… read more here.
Keywords: risk; asparagine; incident; per increase ... See more keywords
The Metabolic Importance of the Overlooked Asparaginase II Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.114084
Abstract: The asparaginase II pathway consists of an asparagine transaminase [L-asparagine + α-keto acid ⇆ α-ketosuccinamate + L-amino acid] coupled to ω-amidase [α-ketosuccinamate + H2O → oxaloacetate + NH4+]. The net reaction is: L-asparagine + α-keto… read more here.
Keywords: asparaginase pathway; asparagine; glyoxylate; pathway ... See more keywords
Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.09.023
Abstract: Mutations of KRAS gene are found in various types of cancer, including colorectal cancer (CRC). Despite intense efforts, no pharmacological approaches are expected to be effective against KRAS-mutant cancers. Macropinocytosis is an evolutionarily conserved actin-dependent… read more here.
Keywords: macropinocytosis; asparagine; kras mutant; crc ... See more keywords
Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00023
Abstract: The multifunctional cytochrome P450 17A1 (CYP17A1) plays a crucial role in human steroid hormone synthesis (UniProtKB─P05093). It first carries out standard monooxygenase chemistry, converting pregnenolone (PREG) and progesterone (PROG) into 17OH-PREG and 17OH-PROG, utilizing a… read more here.
Keywords: cyp17a1; asparagine; preg; active site ... See more keywords
N@a and N@d: Oligomer and Partner Specification by Asparagine in Coiled-Coil Interfaces.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00935
Abstract: The α-helical coiled coil is one of the best-studied protein-protein interaction motifs. As a result, sequence-to-structure relationships are available for the prediction of natural coiled-coil sequences and the de novo design of new ones. However,… read more here.
Keywords: coil sequences; asparagine; coil interfaces; coil ... See more keywords
OsASN1 Plays a Critical Role in Asparagine-Dependent Rice Development
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20010130
Abstract: Asparagine is one of the important amino acids for long-distance transport of nitrogen (N) in plants. However, little is known about the effect of asparagine on plant development, especially in crops. Here, a new T-DNA… read more here.
Keywords: rice development; plays critical; asparagine; osasn1 plays ... See more keywords
Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14010072
Abstract: Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers. Many cancers express reduced… read more here.
Keywords: amino; amino acid; amino acids; starvation ... See more keywords
Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11050669
Abstract: Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly.… read more here.
Keywords: wheat; asparagine; asparagine wheat; low asparagine ... See more keywords
Exploring Variability of Free Asparagine Content in the Grain of Bread Wheat (Triticum aestivum L.) Varieties Cultivated in Italy to Reduce Acrylamide-Forming Potential
Sign Up to like & getrecommendations! Published in 2023 at "Plants"
DOI: 10.3390/plants12061349
Abstract: Acrylamide, a suspected human carcinogen, is generated during food processing at high temperatures in the Maillard reaction, which involves reducing sugars and free asparagine. In wheat derivatives, free asparagine represents a key factor in acrylamide… read more here.
Keywords: asparagine content; asparagine; free asparagine; bread wheat ... See more keywords
Light-Independent Nitrogen Assimilation in Plant Leaves: Nitrate Incorporation into Glutamine, Glutamate, Aspartate, and Asparagine Traced by 15N
Sign Up to like & getrecommendations! Published in 2020 at "Plants"
DOI: 10.3390/plants9101303
Abstract: Although the nitrate assimilation into amino acids in photosynthetic leaf tissues is active under the light, the studies during 1950s and 1970s in the dark nitrate assimilation provided fragmental and variable activities, and the mechanism… read more here.
Keywords: assimilation; nitrogen; nitrogen assimilation; asparagine ... See more keywords