Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.173
Abstract: Hypoxia-inducible factor 1 (HIF-1) is a key player in cellular response to hypoxia. The stability and transcriptional activity of this protein are oxygen-dependently regulated by the prolyl hydroxylases PHD1-3 and the asparaginyl hydroxylase FIH. Recently,… read more here.
Keywords: ferritin heavy; hif; asparaginyl hydroxylase; heavy chain ... See more keywords
Aspartyl (asparaginyl) β-hydroxylase (AABH), a serum biomarker for lung cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.5_suppl.45
Abstract: 45Background: There are no serum biomarkers currently approved for the detection of lung cancer, a leading cause of cancer associated mortality world wide. More than 180,000 cases of lung cancer wi... read more here.
Keywords: asparaginyl hydroxylase; lung cancer; hydroxylase aabh; cancer ... See more keywords
AABH (aspartyl (asparaginyl) β-hydroxylase ) as a serum biomarker for colorectal cancer diagnosis and prognosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.22
Abstract: 22Background: Colorectal cancer (CRC) is the third most common type of cancer diagnosed in the US. The National Comprehensive Cancer Network (NCCN) and the American Cancer Society (ACS) recommend t... read more here.
Keywords: aspartyl asparaginyl; cancer; aabh aspartyl; colorectal cancer ... See more keywords
Modification of Regulatory T Cell Epitopes Promotes Effector T Cell Responses to Aspartyl/Asparaginyl β-Hydroxylase
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012444
Abstract: Cancer is a leading cause of death worldwide. The search for innovative therapeutic approaches is a principal focus of medical research. Vaccine strategies targeting a number of tumor-associated antigens are currently being evaluated. To date,… read more here.
Keywords: cell; aspartyl asparaginyl; asparaginyl hydroxylase; regulatory cell ... See more keywords
Development of a novel anti-human aspartyl-(asparaginyl) β-hydroxylase monoclonal antibody with diagnostic and therapeutic potential.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5642
Abstract: Human aspartyl-(asparaginyl)-β-hydroxylase (HAAH) has recently been the subject of several studies, as it was previously observed to be overexpressed in numerous types of carcinoma cells and tissues in patient tumor samples. HAAH has been implicated… read more here.
Keywords: asparaginyl hydroxylase; antibody; haah; human aspartyl ... See more keywords