N‐Methyl‐D‐Aspartate Receptor Antibodies in Autoimmune Encephalopathy Alter Oligodendrocyte Function
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25699
Abstract: Antibodies against neuronal N‐methyl‐D‐aspartate receptors (NMDARs) in patients with anti‐NMDAR encephalitis alter neuronal synaptic function and plasticity, but the effects on other cells of the nervous system are unknown. read more here.
Keywords: methyl aspartate; aspartate; receptor antibodies; alter ... See more keywords
Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30110
Abstract: Multiple d-amino acids are present in mammalian cells, and these compounds have distinctive physiological functions. Among the free d-amino acids identified in mammals, d-aspartate plays critical roles in the neuroendocrine and endocrine systems, as well… read more here.
Keywords: aspartate; reductase; reductase hydroxypyruvate; mammalian cells ... See more keywords
Recombinant Multi-l-Arginyl-Poly-l-Aspartate (Cyanophycin) as an Emerging Biomaterial.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300170
Abstract: Multi-l-arginyl-poly-l-aspartate (MAPA) is a non-ribosomal polypeptide which synthesis is directed by cyanophycin synthetase, and its production can be achieved using recombinant microorganisms carrying the cphA gene. Along its poly-aspartate backbone, arginine or lysine links to… read more here.
Keywords: aspartate; poly aspartate; multi arginyl; arginyl poly ... See more keywords
One-Pot Biosynthesis of l-Aspartate from Maleic Anhydride via a Thermostable Dual-Enzyme System under High Temperature.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05662
Abstract: l-Aspartate is an important chemical in the food and pharmaceutical industries. Herein, a dual-enzyme system was constructed to synthesize l-aspartate from maleic anhydride at 50 °C, which can reduce the byproduct production. Maleate transformed from… read more here.
Keywords: aspartate maleic; maleic anhydride; enzyme system; high temperature ... See more keywords
Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.8b00700
Abstract: Aspartate (Asp) derivatives are privileged compounds for investigating the roles governed by excitatory amino acid transporters (EAATs) in glutamatergic neurotransmission. Here, we report the synthesis of various Asp derivatives with (cyclo)alkyloxy and (hetero)aryloxy substituents at… read more here.
Keywords: synthesis; aspartate; amino acid; excitatory amino ... See more keywords
Aspartate Glycosylation Triggers Isomerization to Isoaspartate.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b12866
Abstract: O-Linked β-N-acetylglucosamine transferase (OGT) is an essential human enzyme that glycosylates numerous nuclear and cytoplasmic proteins on serine and threonine. It also cleaves Host cell factor 1 (HCF-1) by a mechanism in which the first… read more here.
Keywords: triggers isomerization; aspartate; glycosylation triggers; isomerization isoaspartate ... See more keywords
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Nature immunology"
DOI: 10.1038/s41590-021-01065-2
Abstract: Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the breakdown of self-tolerance are… read more here.
Keywords: mitochondrial aspartate; aspartate; autoimmune; tissue inflammation ... See more keywords
Intake of Aspartate Is Negatively Associated with Overall Cognitive Functioning in College Students (P14-015-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz052.p14-015-19
Abstract: Objectives Certain amino acids are precursors for neurotransmitters (such as tyrosine being a precursor for dopamine) or directly act on receptors in the brain (such as glutamate and aspartate), and ultimately influence brain function. This… read more here.
Keywords: intake aspartate; amino acids; college; aspartate ... See more keywords
DcuA of aerobically grown Escherichia coli serves as a nitrogen shuttle (L‐aspartate/fumarate) for nitrogen uptake
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.14074
Abstract: DcuA of Escherichia coli is known as an alternative C4‐dicarboxylate transporter for the main anaerobic C4‐dicarboxylate transporter DcuB. Since dcuA is expressed constitutively under aerobic and anaerobic conditions, DcuA was suggested to serve aerobically as… read more here.
Keywords: nitrogen shuttle; aspartate; dcua; escherichia coli ... See more keywords
Abstract 3870: The addition of CB-839 to temozolomide significantly reduces glioma aspartate and glutamate in an IDH mutated patient derived glioma xenograft model
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-3870
Abstract: Background: IDH mutated gliomas are critically dependent on glutaminase for glutamate biosynthesis. CB-839 is a novel glutaminase-1 inhibitor which has demonstrated efficacy in both genetically engineered and patient derived IDH mutated glioma cells, especially in… read more here.
Keywords: glutamate; glioma; idh mutated; model ... See more keywords
Abstract P029: Aspartate And Potassium Aspartate May Contribute To A Mechanism By Which Saccharina Japonica Extract Attenuates Hypertension In 2-kidney, 1-clip Renovascular Hypertensive Rats.
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.p029
Abstract: Introduction: Saccharina japonica (SJ) is one of brown algae. The extract of SJ (SJE) is often used for soup stock in Japanese cuisine. We recently observed the decreases in blood pressure (BP) by intake of… read more here.
Keywords: aspartate; sje; asp aspk; hypertension ... See more keywords