Genome‐wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals
Sign Up to like & getrecommendations! Published in 2021 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22392
Abstract: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers for liver health. Here we report the largest genome‐wide association analysis to date of serum ALT and AST levels in over 388k people of European… read more here.
Keywords: genome wide; alt ast; serum alanine; serum ... See more keywords
Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.14822
Abstract: To evaluate the dynamic changes of the aspartate aminotransferase (AST)‐to‐platelet ratio and transient elastography (FibroScan; Echosens, Paris, France) in predicting a histologic response in patients with chronic hepatitis B (CHB) after entecavir treatment. read more here.
Keywords: ratio transient; transient elastography; dynamic changes; aspartate aminotransferase ... See more keywords
Aspartate Aminotransferase-to-Platelet Ratio Index Predicts Liver Failure After Resection of Colorectal Liver Metastases
Sign Up to like & getrecommendations! Published in 2022 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-07333-3
Abstract: Background Chemotherapy agents for metastatic colorectal cancer can cause liver injury, increasing the risk of post-hepatectomy liver failure after hepatectomy for metastases. The role of noninvasive fibrosis markers in this setting is not well established.… read more here.
Keywords: aspartate aminotransferase; index; hepatectomy; failure ... See more keywords
O-26 ASPARTATE AMINOTRANSFERASE, AGE AND D-DIMER IN COVID-19 PATIENTS: A USEFUL PROGNOSTIC MODEL
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hepatology"
DOI: 10.1016/j.aohep.2021.100513
Abstract: Introduction Some patients with SARSCov-2 infection develop severe disease (SARS); however, the factors associated with severity are not yet fully understood. Some reports indicate that liver injury may be a poor prognostic factor. Aim To… read more here.
Keywords: covid patients; age; dimer; model ... See more keywords
Aspartate aminotransferase-to-platelet ratio predicts response to transarterial chemoembolisation and prognosis in hepatocellular carcinoma patients.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical radiology"
DOI: 10.1016/j.crad.2017.09.004
Abstract: AIM To evaluate the value of the aspartate aminotransferase-to-platelet ratio index (APRI) for hepatocellular carcinoma (HCC) patients who underwent transarterial chemoembolisation (TACE). MATERIALS AND METHODS A total of 315 patients were enrolled, who were randomly… read more here.
Keywords: aminotransferase platelet; cohort; training cohort; apri ... See more keywords
Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics
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DOI: 10.1021/acsomega.0c01900
Abstract: Protein dynamics on various time scales from femtoseconds to milliseconds impacts biological function by driving proteins to conformations conducive to ligand binding and creating functional states in enzyme catalysis. Neutron vibrational spectroscopy carried out by… read more here.
Keywords: substrate binding; vibrational dynamics; binding stiffens; picosecond ... See more keywords
Aspartate aminotransferase in COVID‐19: A probably overrated marker
Sign Up to like & getrecommendations! Published in 2021 at "Liver International"
DOI: 10.1111/liv.15068
Abstract: To the Editor, We read with interest the update by Spearman et al1 discussing liver involvement in COVID19. The review mentioned some results about liver enzymes derived from published studies, discussing the frequently reported association… read more here.
Keywords: covid probably; ast; aminotransferase covid; covid19 ... See more keywords
Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe
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DOI: 10.1371/journal.pone.0221975
Abstract: L-aspartate aminotransferase is a pyridoxal 5ʹ-phosphate-dependent transaminase that catalyzes reversible transfer of an α-amino group from aspartate to α-ketoglutarate or from glutamate to oxaloacetate. L-aspartate aminotransferase not only mediates amino acid and carbohydrate metabolism but… read more here.
Keywords: crystal structure; structure aspartate; aspartate aminotransferase; aminotransferase ... See more keywords
Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam
Sign Up to like & getrecommendations! Published in 2022 at "Nagoya Journal of Medical Science"
DOI: 10.18999/nagjms.84.1.19
Abstract: ABSTRACT Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with… read more here.
Keywords: ratio index; platelet ratio; aminotransferase platelet; aspartate aminotransferase ... See more keywords
The Relationship Between Aspartate Aminotransferase To Alanine Aminotransferase Ratio And Metabolic Syndrome In Adolescents In Northeast China
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DOI: 10.2147/dmso.s217127
Abstract: Aim To investigate the relationship of the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and metabolic syndrome (MetS) in adolescents in northeast China. Methods A stratified cluster random sample of 935 students 11–16 years of… read more here.
Keywords: metabolic syndrome; aspartate aminotransferase; relationship aspartate; aminotransferase ... See more keywords
Evaluation of the relationship between aspartate aminotransferase/alanine aminotransferase ratio and coronary slow-flow phenomenon.
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2022-0028
Abstract: Aim: To assess the correlation between the ratio of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and slow coronary flow (SCF). Methods: A total of 119 patients with SCF and 121 age- and sex-matched patients… read more here.
Keywords: coronary flow; aminotransferase; alanine aminotransferase; flow ... See more keywords