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Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation.

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0 Published in 2018 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.04.041

Abstract: Cholangiocarcinoma (CCA) is a highly lethal and aggressive disease. Recently, IDH1/2 mutations have been identified in approximately 20% of CCAs which suggests an involvement of 2-oxoglutarate (2-OG) -dependent dioxygenases in oncogenesis. We investigated if the… read more here.

Keywords: aspartate beta; rb1 phosphorylation; modulating rb1; progression ... See more keywords