Electrostatic fingerprints of catalytically active amino acids in enzymes
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DOI: 10.1002/pro.4291
Abstract: The computed electrostatic and proton transfer properties are studied for 20 enzymes that represent all six major enzyme commission classes and a variety of different folds. The properties of aspartate, glutamate, and lysine residues that… read more here.
Keywords: electrostatic fingerprints; aspartate glutamate; catalytically active; intrinsic pka ... See more keywords
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling
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DOI: 10.1038/s41598-019-42554-7
Abstract: Pathogenic variants of OPA1, which encodes a dynamin GTPase involved in mitochondrial fusion, are responsible for a spectrum of neurological disorders sharing optic nerve atrophy and visual impairment. To gain insight on OPA1 neuronal specificity,… read more here.
Keywords: metabolomic signature; glutamate; aspartate glutamate; deficiency ... See more keywords
Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (SLC25A13): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells
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DOI: 10.3390/ijms20081888
Abstract: Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. For this reason, mitochondrial carrier gene expression needs tight regulation. The human SLC25A13 gene,… read more here.
Keywords: aspartate; aspartate glutamate; carrier; gene ... See more keywords
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo
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DOI: 10.3390/ijms20184486
Abstract: Aspartate-Glutamate Carrier 1 (AGC1) deficiency is a rare neurological disease caused by mutations in the solute carrier family 25, member 12 (SLC25A12) gene, encoding for the mitochondrial aspartate-glutamate carrier isoform 1 (AGC1), a component of… read more here.
Keywords: glutamate carrier; proliferation; carrier; aspartate glutamate ... See more keywords
Aspartate-glutamate carrier 2 (citrin): a role in glucose and amino acid metabolism in the liver.
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DOI: 10.5483/bmbrep.2023-0052
Abstract: Aspartate-glutamate carrier 2 (AGC2, citrin) is a mitochondrial carrier expressed in the liver that transports aspartate from mitochondria into cytosol in exchange with glutamate. The AGC2 is the main component of malate-aspartate shuttle (MAS) that… read more here.
Keywords: aspartate glutamate; liver; glutamate; glutamate carrier ... See more keywords