Implication of Genes for the N-Methyl-d-Aspartate (NMDA) Receptor in Substance Addictions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0877-3
Abstract: Drug dependence is a chronic brain disease with harmful consequences for both individual users and society. Glutamate is a primary excitatory neurotransmitter in the brain, and both in vivo and in vitro experiments have implicated… read more here.
Keywords: methyl aspartate; implication genes; etiology; nmda receptor ... See more keywords
Persistent Overexposure to N-Methyl-d-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9958-3
Abstract: Astrocytes express N-methyl-d-aspartate (NMDA) receptor (NMDAR) but its functions in these cells are not well defined. This study shows that the sustained exposure (8–72 h) of mouse astrocytes to NMDA decreases the expression of the functional… read more here.
Keywords: methyl aspartate; glutamine synthetase; kir4; aspartate nmda ... See more keywords
A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112447
Abstract: l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS), which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel belonging to the iGluRs family. Among… read more here.
Keywords: methyl aspartate; comprehensive description; glun2b; nmda receptor ... See more keywords
Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2016.11.009
Abstract: Tiletamine is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist chemically related to ketamine and phencyclidine. A common veterinary anesthetic drug, tiletamine is currently a Schedule III controlled substance in USA. This compound exerts sedative effects in… read more here.
Keywords: competitive methyl; methyl aspartate; tiletamine adult; non competitive ... See more keywords
A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near N-methyl-D-aspartate (NMDA) receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05512g
Abstract: Glutathione (GSH) is known to play a key role in the modulation of the redox environment in N-methyl-d-aspartate (NMDA) receptors. Coumarin derivative 1 bearing cyanoacrylamide and ifenprodil moieties was synthesized and reported to monitor GSH… read more here.
Keywords: gsh; aspartate nmda; methyl aspartate; nmda receptors ... See more keywords