Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection.
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DOI: 10.1021/jacs.9b06061
Abstract: O-GlcNAc is an abundant post-translational modification found on nuclear and cytoplasmic proteins in all metazoans. This modification regulates a wide variety of cellular processes, and elevated O-GlcNAc levels have been implicated in cancer progression. A… read more here.
Keywords: glcnac; aspartate residues; substrate selection; glcnac transferase ... See more keywords