Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.112
Abstract: Aspartate transcarbamoylase catalyzes the second step of de-novo pyrimidine biosynthesis. As malarial parasites lack pyrimidine salvage machinery and rely on de-novo production for growth and proliferation, this pathway is a target for drug discovery. Previously,… read more here.
Keywords: transcarbamoylase; plasmodium falciparum; aspartate transcarbamoylase;
Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21165-9
Abstract: Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC… read more here.
Keywords: active sites; firing active; plant; aspartate transcarbamoylase ... See more keywords
Characterization and assembly of the Pseudomonas aeruginosa aspartate transcarbamoylase-pseudo dihydroorotase complex
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229494
Abstract: Pseudomonas aeruginosa is a virulent pathogen that has become more threatening with the emergence of multidrug resistance. The aspartate transcarbamoylase (ATCase) of this organism is a dodecamer comprised of six 37 kDa catalytic chains and… read more here.
Keywords: chain; pseudomonas aeruginosa; aspartate transcarbamoylase; atcase ... See more keywords
Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.841833
Abstract: Malaria remains one of the most prominent and dangerous tropical diseases. While artemisinin and analogs have been used as first-line drugs for the past decades, due to the high mutational rate and rapid adaptation to… read more here.
Keywords: aspartate transcarbamoylase; transcarbamoylase; drug; aspartate ... See more keywords
Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041585
Abstract: Aspartate transcarbamoylase (ATC) catalyzes the first committed step in pyrimidine de novo synthesis. As shown before, mutants with 80% reduced transcript and protein levels exhibit reduced levels of pyrimidine metabolites and thus nucleotide limitation and… read more here.
Keywords: aspartate transcarbamoylase; imbalance; acclimation arabidopsis; cold acclimation ... See more keywords