Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
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DOI: 10.1038/s41467-020-14755-6
Abstract: Although peptide chemistry has made great progress, the frequent occurrence of aspartimide formation during peptide synthesis remains a formidable challenge. Aspartimide formation leads to low yields in addition to costly purification or even inaccessible peptide… read more here.
Keywords: chemistry; peptide synthesis; formation peptide; aspartimide formation ... See more keywords