Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
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DOI: 10.1002/cmdc.202000024
Abstract: Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one‐step syntheses are a powerful approach for the fast discovery of novel bioactive molecules. Here, we are presenting a pipeline for… read more here.
Keywords: discovery aspartyl; discovery; aspartyl protease; protease inhibitors ... See more keywords
Importance of aspartyl protease 5 in the establishment of the intracellular niche during acute and chronic infection of Toxoplasma gondii
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DOI: 10.1111/mmi.14987
Abstract: Virulence and persistence of the obligate intracellular parasite Toxoplasma gondii involve the secretion of effector proteins belonging to the family of dense granule proteins (GRAs) that act notably as modulators of the host defense mechanisms… read more here.
Keywords: toxoplasma gondii; aspartyl protease;