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   Articles with "aspartyl trna" as a keyword



In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL

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recommendations! Published in 2017 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2016.10.008

Abstract: BACKGROUND The recently diagnosed leukodystrophy Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL) is caused by mutations of the cytoplasmic aspartyl-tRNA synthetase geneDARS. The physiological role of DARS in translation is… read more here.

Keywords: aspartyl trna; trna synthetase; leukodystrophy; mice ... See more keywords

Bacillus subtilis Utilizes Decarboxylated S-Adenosylmethionine for the Biosynthesis of Tandem Aminopropylated Microcin C, a Potent Inhibitor of Bacterial Aspartyl-tRNA Synthetase.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c18468

Abstract: The biosynthetic pathways of natural products involve unusual biochemical reactions catalyzed by unique enzymes. Aminopropylation, although apparently simple, is an extremely rare modification outside polyamine biosynthesis. The canonical pathway used in the biosynthesis of peptide-adenylate… read more here.

Keywords: aspartyl trna; bacillus subtilis; trna synthetase; biosynthesis ... See more keywords

Discovery and Characterization of Chemical Compounds That Inhibit the Function of Aspartyl-tRNA Synthetase from Pseudomonas aeruginosa

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recommendations! Published in 2018 at "SLAS Discovery"

DOI: 10.1177/2472555217744559

Abstract: Pseudomonas aeruginosa, an opportunistic pathogen, is highly susceptible to developing resistance to multiple antibiotics. The gene encoding aspartyl-tRNA synthetase (AspRS) from P. aeruginosa was cloned and the resulting protein characterized. AspRS was kinetically evaluated, and… read more here.

Keywords: trna synthetase; pseudomonas aeruginosa; chemical compounds; aspartyl trna ... See more keywords

Secreted mitochondrial aspartyl‐tRNA synthetase (DARS2) regulates TNFα signaling

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recommendations! Published in 2025 at "Physiological Reports"

DOI: 10.14814/phy2.70627

Abstract: Aminoacyl‐tRNA Synthetases (aaRS) are important regulators of cytokine signaling. Multiple cytoplasmic aaRS family members have been observed to be secreted in response to various stimuli to modulate downstream responses, however, agonist‐induced cellular release of aaRS… read more here.

Keywords: aspartyl trna; dars2; trna; trna synthetase ... See more keywords

Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity

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recommendations! Published in 2019 at "Genes"

DOI: 10.3390/genes10040262

Abstract: The aminoacyl-tRNA synthetases (aaRSs) are well established as the translators of the genetic code, because their products, the aminoacyl-tRNAs, read codons to translate messenger RNAs into proteins. Consequently, deleterious errors by the aaRSs can be… read more here.

Keywords: trna synthetase; glutamyl trna; synthetase; aspartyl trna ... See more keywords