In vivo characterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL
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DOI: 10.1016/j.nbd.2016.10.008
Abstract: BACKGROUND The recently diagnosed leukodystrophy Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL) is caused by mutations of the cytoplasmic aspartyl-tRNA synthetase geneDARS. The physiological role of DARS in translation is… read more here.
Keywords: aspartyl trna; trna synthetase; leukodystrophy; mice ... See more keywords
Discovery and Characterization of Chemical Compounds That Inhibit the Function of Aspartyl-tRNA Synthetase from Pseudomonas aeruginosa
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DOI: 10.1177/2472555217744559
Abstract: Pseudomonas aeruginosa, an opportunistic pathogen, is highly susceptible to developing resistance to multiple antibiotics. The gene encoding aspartyl-tRNA synthetase (AspRS) from P. aeruginosa was cloned and the resulting protein characterized. AspRS was kinetically evaluated, and… read more here.
Keywords: trna synthetase; pseudomonas aeruginosa; chemical compounds; aspartyl trna ... See more keywords
Bacterial Aspartyl-tRNA Synthetase Has Glutamyl-tRNA Synthetase Activity
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DOI: 10.3390/genes10040262
Abstract: The aminoacyl-tRNA synthetases (aaRSs) are well established as the translators of the genetic code, because their products, the aminoacyl-tRNAs, read codons to translate messenger RNAs into proteins. Consequently, deleterious errors by the aaRSs can be… read more here.
Keywords: trna synthetase; glutamyl trna; synthetase; aspartyl trna ... See more keywords