Fundamental aspects of DMPK optimization of targeted protein degraders.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.03.012
Abstract: Targeted protein degraders are an emerging modality. Their properties fall outside the traditional small-molecule property space and are in the 'beyond rule of 5' space. Consequently, drug discovery programs focused on developing orally available degraders… read more here.
Keywords: aspects dmpk; protein degraders; optimization; targeted protein ... See more keywords