Computational studies on structural aspects of pyrazolo[3,4-b]pyridine derivatives as TRKA inhibitors in cancer therapy
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DOI: 10.1038/s41598-025-08370-y
Abstract: Tropomyosin receptor kinases (TRKs) play a crucial role in nerve development, and their dysregulation due to genetic alterations, such as NTRK fusions, has been linked to various cancers. Recently, TRKs have emerged as effective therapeutic… read more here.
Keywords: studies structural; structural aspects; aspects pyrazolo; pyrazolo pyridine ... See more keywords