A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24801
Abstract: Neonatal encephalopathy (NE) that purportedly arises from hypoxia-ischemia is labeled hypoxic-ischemic encephalopathy (HIE). Perinatal asphyxia is a clinical syndrome involving acidosis, a low Apgar score and the need for resuscitation in the delivery room; asphyxia… read more here.
Keywords: asphyxia; systematic review; brain injury; hie ... See more keywords
Letter to the Editor regarding the article ‘ER stress-related protein, CHOP, may serve as a biomarker of mechanical asphyxia: a primary study’ by Hu and colleagues
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-022-02808-y
Abstract: We read with interest the article recently published by Hu and colleagues [1]. Basing on growing evidence linking cellular hypoxia induced by mechanical asphyxia to mitochondrial disfunction, the authors proposed a mitochondria-related protein — namely… read more here.
Keywords: mechanical asphyxia; damage; related protein; article ... See more keywords
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia
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DOI: 10.1016/j.redox.2017.02.002
Abstract: Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia is a leading cause of mortality and acquired long-term neurologic co-morbidities in the neonate. The most successful intervention for the treatment of moderate to severe HIE is moderate… read more here.
Keywords: piglet model; metabolite score; asphyxia; hypoxia time ... See more keywords
Associations between low birth weight and perinatal asphyxia: A hospital-based study
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DOI: 10.1097/md.0000000000033137
Abstract: To investigate the associations between low birth weight (LBW) and perinatal asphyxia by a hospital-based study. The participants of this study were mothers who gave birth at our hospital in 2018. They were divided into… read more here.
Keywords: associations low; perinatal asphyxia; hospital; asphyxia ... See more keywords
Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia
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DOI: 10.1111/epi.16963
Abstract: Seizures are common in neonates recovering from birth asphyxia but there is general consensus that current pharmacotherapy is suboptimal and that novel antiseizure drugs are needed. We recently showed in a rat model of birth… read more here.
Keywords: carbonic anhydrase; model birth; asphyxia; birth asphyxia ... See more keywords
Impact of perinatal asphyxia on parental mental health and bonding with the infant: a questionnaire survey of Swiss parents
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Paediatrics Open"
DOI: 10.1136/bmjpo-2017-000059
Abstract: Objective To compare current mental health symptoms and infant bonding in parents whose infants survived perinatal asphyxia in the last 2 years with control parents and to investigate which sociodemographic, obstetric and neonatal variables correlated with… read more here.
Keywords: questionnaire survey; asphyxia; perinatal asphyxia; mental health ... See more keywords
Asphyxia in the Newborn: Evaluating the Accuracy of ICD Coding, Clinical Diagnosis and Reimbursement: Observational Study at a Swiss Tertiary Care Center on Routinely Collected Health Data from 2012-2015
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DOI: 10.1371/journal.pone.0170691
Abstract: Background The ICD-10 categories of the diagnosis “perinatal asphyxia” are defined by clinical signs and a 1-minute Apgar score value. However, the modern conception is more complex and considers metabolic values related to the clinical… read more here.
Keywords: diagnosis; asphyxia; study; routinely collected ... See more keywords
Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00447
Abstract: Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical… read more here.
Keywords: blood brain; asphyxia; post asphyxial; brain barrier ... See more keywords
Inadequate Bioavailability of Intramuscular Epinephrine in a Neonatal Asphyxia Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.828130
Abstract: Background Over half a million newborn deaths are attributed to intrapartum related events annually, the majority of which occur in low resource settings. While progress has been made in reducing the burden of asphyxia, novel… read more here.
Keywords: inadequate bioavailability; epinephrine; bioavailability intramuscular; asphyxia ... See more keywords
Pathophysiology of Perinatal Asphyxia in Humans and Animal Models
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DOI: 10.3390/biomedicines10020347
Abstract: Perinatal asphyxia is caused by lack of oxygen delivery (hypoxia) to end organs due to an hypoxemic or ischemic insult occurring in temporal proximity to labor (peripartum) or delivery (intrapartum). Hypoxic–ischemic encephalopathy is the clinical… read more here.
Keywords: asphyxia humans; animal models; perinatal asphyxia; humans animal ... See more keywords
Newborn Mortality in Sub-Saharan Africa: Why is Perinatal Asphyxia Still a Major Cause?
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DOI: 10.5334/aogh.2541
Abstract: Abstract Global new-born mortality has shown steady decline over the last two decades, but this decline has been slowest in Sub-Saharan Africa (SSA). Perinatal asphyxia (PA) is a major cause of new-born deaths in this… read more here.
Keywords: major cause; asphyxia; perinatal asphyxia; mortality ... See more keywords