Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06240-0
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by immune cells dysfunction. This study aimed to investigate the molecular mechanisms involved in AERD pathogenesis. Relevant literatures were identified by a PubMed search (2005-2019) of english language papers… read more here.
Keywords: disease aerd; aspirin exacerbated; respiratory disease; disease ... See more keywords
Aspirin-Exacerbated Respiratory Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Otolaryngologic clinics of North America"
DOI: 10.1016/j.otc.2016.08.007
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of… read more here.
Keywords: aspirin exacerbated; respiratory disease; disease; aspirin ... See more keywords
Cellular interactions in aspirin-exacerbated respiratory disease
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000712
Abstract: Purpose of review The purpose of this review is to summarize the complex cellular interactions of aspirin-exacerbated respiratory disease (AERD) and how these interactions promote pathogenic mechanisms of AERD. Recent findings In addition to characteristic… read more here.
Keywords: exacerbated respiratory; respiratory disease; interactions aspirin; aspirin exacerbated ... See more keywords
Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-017-0556-6
Abstract: BackgroundWe previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV1) after an oral… read more here.
Keywords: aspirin exacerbated; association; ilvbl gene; ilvbl ... See more keywords
Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240334
Abstract: Background Patients with aspirin-exacerbated respiratory disease (AERD) are known to have poor clinical outcomes. The pathogenic mechanisms have not yet been completely understood. Objective We aimed to assess the involvement of the de-novo synthetic pathway… read more here.
Keywords: aspirin exacerbated; respiratory disease; patients aerd; expression serine ... See more keywords
Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.850494
Abstract: Chronic rhinosinusitis with nasal polyps is affecting up to 3% of Western populations. About 10% of patients with nasal polyps also suffer from asthma and intolerance to aspirin, a syndrome called aspirin-exacerbated respiratory disease. Although… read more here.
Keywords: nasal polyps; exacerbated respiratory; respiratory disease; aspirin exacerbated ... See more keywords
Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13111920
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and… read more here.
Keywords: exacerbated respiratory; respiratory disease; aspirin exacerbated; group ... See more keywords
Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12030447
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study… read more here.
Keywords: exacerbated respiratory; disease; sensitization; aspirin exacerbated ... See more keywords