ASPM promotes hepatocellular carcinoma progression by activating Wnt/β‐catenin signaling through antagonizing autophagy‐mediated Dvl2 degradation
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13278
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article, we show that expression of abnormal spindle‐like microcephaly‐associated protein (ASPM) is up‐regulated in liver cancer samples, and this up‐regulation is significantly… read more here.
Keywords: hepatocellular carcinoma; catenin signaling; autophagy mediated; dvl2 ... See more keywords
Identification of a Novel Nonsense ASPM Mutation in a Large Consanguineous Pakistani Family Using Targeted Next-Generation Sequencing.
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DOI: 10.1089/gtmb.2017.0229
Abstract: AIMS To identify the pathogenic mutation underlying microcephaly primary hereditary (MCPH) in a large consanguineous Pakistani family. METHODS A five-generation family with an autosomal recessive transmission of MCPH was recruited. Targeted next-generation DNA sequencing was… read more here.
Keywords: large consanguineous; family; generation; aspm ... See more keywords
Oncogenic role of abnormal spindle-like microcephaly-associated protein in lung adenocarcinoma
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DOI: 10.3892/ijo.2021.5203
Abstract: Lung adenocarcinoma (LUAD) is a common malignant cancer worldwide. It is urgent to explore its underlying molecular mechanism and identify novel diagnostic biomarkers. Abnormal spindle-like microcephaly (ASPM) has recently received considerable attention due to its… read more here.
Keywords: lung adenocarcinoma; luad; spindle like; abnormal spindle ... See more keywords