ASPP2 Inhibits the Profibrotic Effects of Transforming Growth Factor-β1 in Hepatic Stellate Cells by Reducing Autophagy
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DOI: 10.1007/s10620-017-4816-3
Abstract: BackgroundApoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis. Fibrosis is a wound-healing response, and hepatic stellate cells (HSCs) are key players in liver fibrogenesis. However, little is known about… read more here.
Keywords: fibrosis; tgf; hepatic stellate; aspp2 ... See more keywords
Abstract 2535: Inhibition of oncogenic ASPP2kappa(k), a dominant-negative isoform of the tumorsuppressor ASPP2, results in reactivation of p53 in glioblastoma
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DOI: 10.1158/1538-7445.am2023-2535
Abstract: GB is the most common, most aggressive primary brain tumor with a deleterious prognosis. Novel approaches to improve therapy are urgently needed. ASPP2 is a tumor suppressor, directly interacting with p53 to induce apoptosis. We… read more here.
Keywords: aspp2; apoptosis; aspp2k; p53 ... See more keywords
ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α
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DOI: 10.3389/fphar.2022.865389
Abstract: Background: Though ASPP2 plays an important role in regulating cell apoptosis and autophagy in case of liver injury, there remains a lack of clarity on the molecular mechanism of ASPP2 regulating autophagy and apoptosis. Methods:… read more here.
Keywords: aspp2; apoptosis; autophagy apoptosis; mtorc1 ... See more keywords