Abstract 2535: Inhibition of oncogenic ASPP2kappa(k), a dominant-negative isoform of the tumorsuppressor ASPP2, results in reactivation of p53 in glioblastoma
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DOI: 10.1158/1538-7445.am2023-2535
Abstract: GB is the most common, most aggressive primary brain tumor with a deleterious prognosis. Novel approaches to improve therapy are urgently needed. ASPP2 is a tumor suppressor, directly interacting with p53 to induce apoptosis. We… read more here.
Keywords: aspp2; apoptosis; aspp2k; p53 ... See more keywords