Aspulvins A–H, Aspulvinone Analogues with SARS-CoV-2 Mpro Inhibitory and Anti-inflammatory Activities from an Endophytic Cladosporium sp.
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DOI: 10.1021/acs.jnatprod.1c01003
Abstract: Eight new aspulvinone analogues, aspulvins A–H (1–8) and aspulvinones D, M, O, and R (9–12), were isolated from cultures of the endophytic fungus Cladosporium sp. 7951. Detailed spectroscopic analyses were conducted to determine the structures… read more here.
Keywords: cov mpro; anti inflammatory; aspulvinone analogues; aspulvins aspulvinone ... See more keywords
Collective synthesis of aspulvinone and its analogues by vinylogous aldol condensation of substituted tetronic acids with aldehydes
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DOI: 10.1039/d2ra08133d
Abstract: A mild, modular and efficient synthetic method with broad substrate scope was developed for aspulvinones. Nine natural aspulvinones were synthesized, six of which were for the first time. The aldol condensation delivered Z-configuration products predominantly… read more here.
Keywords: synthesis aspulvinone; condensation; collective synthesis; aspulvinone analogues ... See more keywords