Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
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DOI: 10.1002/hep.29884
Abstract: Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, Argininosuccinate Synthase 1 (ASS1), a major periportal protein, was proposed as a marker of HCA with… read more here.
Keywords: sonic hedgehog; hca; expression; ass1 expression ... See more keywords
Abstract B38: Molecular mechanisms and therapeutic implications of argininosuccinate synthesis 1 regulation in targeted arginine- and glutamine-starvation cancer therapy
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DOI: 10.1158/1557-3265.tcm17-b38
Abstract: Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg). Many malignant human tumors are auxotrophic for Arg because ASS1 is silenced. We previously demonstrated that ASS1 is a sensor… read more here.
Keywords: therapy; starvation; arg gln; cancer ... See more keywords