Development of an ELISpot Assay for the Assessment of AAV Peptides to Examine Immune Safety.
Sign Up to like & getrecommendations! Published in 2024 at "Human gene therapy"
DOI: 10.1089/hum.2023.180
Abstract: Adeno-associated virus (AAV)-based gene therapies have shown promise as novel treatments for rare genetic disorders such as Haemophilia A and Spinal Muscular Atrophy. However, cellular immune responses mediated by cytotoxic (CD8+) and helper (CD4+) T… read more here.
Keywords: aav; assay assessment; elispot; development elispot ... See more keywords
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032914
Abstract: In vitro determination of hemolytic properties is a common and important method for preliminary evaluation of cytotoxicity of chemicals, drugs, or any blood-contacting medical device or material. The method itself is relatively straightforward, however, protocols… read more here.
Keywords: cytotoxicity; assay assessment; hemolysis; optimization hemolysis ... See more keywords